24 research outputs found

    Fostering cooperation between farmers and public and private actors to expand environmentally friendly rice cultivation: intermediary functions and farmers’ perspectives

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    This study investigates the intermediary functions and the farmers’ perspectives in the development and implementation of agri-environmental schemes in Shiga Prefecture of Japan by employing the innovation journey analysis and the statistical analysis. The innovation journey analysis demonstrates that the prefectural government served as an ‘innovation intermediary’ to: (1) provide a clear vision of sustainable agriculture for farmers and other actors, (2) create and reinforce both technological and market niches and (3) develop actor networks involving local actors. It also identifies the following roles of the Japan Agricultural Cooperatives (JAs) and the specialist wholesaler as innovation intermediaries to: (1) develop new farming materials such as fertilizers, (2) translate and deliver practical farming knowledge for farmers and (3) establish the market of environmental-friendly rice. Statistical analysis uncovers that farmers more appreciated the supports from the JAs than those from other intermediaries to participate in the schemes. Complemented by the innovation journey analysis, our findings suggest that the keys to increasing farmers’ participation in the schemes include a clear vision and economic incentives for farmers as well as the coordination among intermediaries who have different expertise

    Implications of Systemic Inflammation and Periodontitis for Major Depression

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    Increasing evidence suggests that infection and persistent low-grade inflammation in peripheral tissues are important pathogenic factors in major depression. Major depression is frequently comorbid with systemic inflammatory diseases/conditions such as rheumatoid arthritis, allergies of different types, multiple sclerosis, cardiovascular disease, inflammatory bowel disease, chronic liver disease, diabetes, and cancer, in which pro-inflammatory cytokines are overexpressed. A number of animal studies demonstrate that systemic inflammation induced by peripheral administration of lipopolysaccharide increases the expression of pro-inflammatory cytokines in both the periphery and brain and causes abnormal behavior similar to major depression. Systemic inflammation can cause an increase in CNS levels of pro-inflammatory cytokines associated with glial activation, namely, neuroinflammation, through several postulated pathways. Such neuroinflammation can in turn induce depressive moods and behavioral changes by affecting brain functions relevant to major depression, especially neurotransmitter metabolism. Although various clinical studies imply a causal relationship between periodontitis, which is one of the most common chronic inflammatory disorders in adults, and major depression, the notion that periodontitis is a risk factor for major depression is still unproven. Additional population-based cohort studies or prospective clinical studies on the relationship between periodontitis and major depression are needed to substantiate the causal link of periodontitis to major depression. If such a link is established, periodontitis may be a modifiable risk factor for major depression by simple preventive oral treatment

    The Possible Causal Link of Periodontitis to Neuropsychiatric Disorders: More Than Psychosocial Mechanisms

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    Increasing evidence implies a possible causal link between periodontitis and neuropsychiatric disorders, such as Alzheimer’s disease (AD) and major depression (MD). A possible mechanism underlying such a link can be explained by neuroinflammation induced by chronic systemic inflammation. This review article focuses on an overview of the biological and epidemiological evidence for a feasible causal link of periodontitis to neuropsychiatric disorders, including AD, MD, Parkinson’s disease, and schizophrenia, as well as the neurological event, ischemic stroke. If there is such a link, a broad spectrum of neuropsychiatric disorders associated with neuroinflammation could be preventable and modifiable by simple daily dealings for oral hygiene. However, the notion that periodontitis is a risk factor for neuropsychiatric disorders remains to be effectively substantiated
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